Then use your science to flip the polarity and pack alignment to prove your theory, you have everything there to confirm what SMC has published, they are very reputable and not "blowing smoke", ha!
The SMC article I referenced above does a great job explaining the problems with running packs in series... you increase IR across the lead between the packs which in turn generates heat. You can "scientifically" measure the temps of both packs at the end of a run to see for yourself that the...
Going 2S will be more expensive in the long run as the 2S batteries will be less efficient and be worked harder pushing more than double the current which will create excess heat and cause the batteries to wear out faster and need replacement sooner than 4S
4S is very efficient, in fact I have ran 6S with Deans without any failures... only problem I've had with Deans are 2S on SCT which pulls way too much current with a 4600KV motor.
That said for a 2200KV motor on 4S, Deans and/or XT60 will do perfectly fine.